Isoproterenol이 백서구강점막의 비만세포에 미치는 영향
Effects of Isoproterenol on the Mast Cells in The Oral Mucosa of Albino Rats
고재승, 송완영,
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고재승 ( Go Jae-Seung ) - 서울대학교 치과대학 구강해부학교실
송완영 ( Song Wan-Young ) - 서울대학교 치과대학 구강해부학교실
KMID : 0362719730110060383
Abstract
The effects of isoproterenol, a sympathomimetic amine, on the mast cells in the oral mucosa were cytochemically studied in twenty four healthy male albino rats weighing approximately 100gm. seven groups of three each were injected intraperitoneally, as a single dose of 8mg/100gm. body wt., (dissolved in 0.9% saline 0.2㎖). Each groups were sacrificed following ether anesthesia at he time indicated, 1. 2. 3. 5. 7. 10. 14days after only a single injection. One normal group is not administered with any substances. The sections of oral mucosa were stained with 0.005% toluidine blue (Mowry’s method) and alcian blue (pH 2.5). We found that isoproterenol made an initial decrease in the metachromasia and alcian blue affinity, and the number of mast cell, followed by an subsequent return to normal.
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